Effect of valeric syrup on preoperative anxiety compared with diazepam and placebo

moshtaghion, Hossein; ahmadi, mohammadsadegh; vaziribozorg, sedighe

Journal of Emergency Health Care

Formerly known as: International Journal of Medical Investigation

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Volume 5, Issue 1 (march 2016) J Emerg Health Care 2016, 5(1): 12-16 | Back to browse issues page

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moshtaghion H, ahmadi M, vaziribozorg S. Effect of valeric syrup on preoperative anxiety compared with diazepam and placebo. J Emerg Health Care 2016; 5 (1) :12-16
URL: http://intjmi.com/article-1-216-en.html

Effect of valeric syrup on preoperative anxiety compared with diazepam and placebo

Hossein Moshtaghion

, Mohammadsadegh Ahmadi

, Sedighe Vaziribozorg ^*

researcher, medicine doctor, pain research center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Abstract: (8554 Views)

Abstract
Objective: Pre anesthetic anxiety is a major challenge for both patients and anesthesiologist. The reported incidence of preoperative anxiety in adults ranges from 11% to 80%. Preoperative medication has an important role to reduce the preoperative anxiety. One of these medicines is valeric syrup that contains extracts of valerian and Melissa Officinal’s (Lemon balm). Valerian is an herb with sedative and hypnotic properties and contains valepotriate and valeric acid. Lemon balm is an another herb that used as an anxiolytic, mild sedative or calming agent . In this study, we evaluate the effect of valeric syrup on preoperative anxiety compared with diazepam and placebo.
Methods: Ninety patients were evaluated in this randomized, double blind clinical trial study. All patients older than 15 years old with American Society of Anaesthesia (ASA) physical status 1-2 underwent a surgical producer were included in this study. Patients assigned into one of the three groups (valeric, diazepam and placebo group), (30 Patients in each group) according to random –number table. The day before surgery Patients were visited and vas score , systolic blood pressure, diastolic blood pressure and heart rate recorded for each Patient. 10 hours before the procedure group 1 received 15mg valeric syrup, group 2 received 10 mg diazepam and group 3 received placebo. For the second time 1 hour before the procedure group 1 received 15mg valeric syrup, group 2 received 10 mg diazepam and group 3 received placebo. Vas score , systolic blood pressure, diastolic blood pressure and heart rate recorded before the procedure beginning again.
Results: Ninety patients in three groups (valeric, diazepam and placebo) were compared. There was no significant difference in mean vas score between three groups but mean vas score was lower in valeric group after intervention. There was no significant difference in mean hemodynamic changes (systolic blood pressure, diastolic blood pressure and heart rate) between three groups, but mean diastolic blood pressure and mean heart rate was lower in valeric group after intervention. There was a significant difference in patient angriness and obedience, but not about the other adverse effects.
Conclusion: According to our results since mean vas score, mean diastolic blood pressure and mean heart rate was lower in valeric group after the intervention and there was no significant difference in mean hemodynamic changes between three groups, valeric syrup is an appropriate option to preventing preoperative anxiety compared with diazepam and placebo.

Keywords: Valeric syrup, Preoperative anxiety, Diazepam

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Type of Study: Research | Subject: General

References

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