Journal of Emergency Health Care
Formerly known as: International Journal of Medical Investigation
Volume 13, Issue 4 (12-2024)
J Emerg Health Care 2024, 13(4): 155-168 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Gharehbakhshi F, Abdolmohammadi G, Yeganeh P M, Mirzaei M, Alvandi F, Behnag E K. Is There a Relation between Brain MRI Active Plaques and Cognitive Disorders in Multiple Sclerosis?. J Emerg Health Care 2024; 13 (4) :155-168
URL: http://intjmi.com/article-1-1220-en.html
URL: http://intjmi.com/article-1-1220-en.html
Farshad Gharehbakhshi 
, Golmis Abdolmohammadi , Pegah Moharrami Yeganeh * , Mehdi Mirzaei , Farzaneh Alvandi , Ehsan Karimi Behnag
, Golmis Abdolmohammadi , Pegah Moharrami Yeganeh * , Mehdi Mirzaei , Farzaneh Alvandi , Ehsan Karimi Behnag
School of Medicine Zanjan University of Medical Science, Zanjan, Iran
Abstract: (243 Views)
Mood disorders could be frequently observed in multiple sclerosis (MS) patients. Mood disorders are common condition in multiple sclerosis with high prevalence rates, for example annually prevalence rate of depression is as high as 20% and lifetime prevalence rates is 50%. In addition it observed that bipolar disoder and other cognitive disorders were common in these patients. However, the comorbidity of psychiatric problems and amont of brain damage is not clear. Therfore, this study aimed to investigate the correlation between the active plaques of MS cases' brain MRI and co-occurrence of different cognitive disorders in the same patients. This literature review project was designed based on standard guidelines to evaluate the related data about brain MRI active plaques and cognitive disorders in multiple sclerosis. The study words, which were combined with each other, were “Mood Disorders”, “Active Plaques”, “Multiple Sclerosis”, “MRI”, “Depression”, “Cognitive disorders”, and “Bipolar Disorder”, the data were extracted and compared. The evaluated studies have represented that there is a correlation between depression and the amount of active plaques on the anterior parietal and left temporal area of the MS patients.
Keywords: Multiple Sclerosis, Active Plaques, MRI, Cognitive disorders, Mood Disorders, Depression, and Bipolar Disorder.
References
1. 1. Arnett PA, Barwick FH, Beeney JE. Depression in multiple sclerosis: review and theoretical proposal. Journal of the International Neuropsychological Society. 2008;14(5):691-724.
2. Feinstein A. Multiple sclerosis and depression. Multiple Sclerosis Journal. 2011;17(11):1276-81.
3. Carta M, Moro MF, Lorefice L, Trincas G, Cocco E, Del Giudice E, et al. The risk of bipolar disorders in multiple sclerosis. Journal of affective disorders. 2014;155:255-60.
4. Womer FY, Wang L, Alpert KI, Smith MJ, Csernansky JG, Barch DM, et al. Basal ganglia and thalamic morphology in schizophrenia and bipolar disorder. Psychiatry Research: Neuroimaging. 2014;223(2):75-83.
5. Moore P, Hirst C, Harding KE, Clarkson H, Pickersgill TP, Robertson NP. Multiple sclerosis relapses and depression. Journal of psychosomatic research. 2012;73(4):272-6.
6. Dalton EJ, Heinrichs RW. Depression in multiple sclerosis: a quantitative review of the evidence. Neuropsychology. 2005;19(2):152.
7. Luo X, Mao Q, Shi J, Wang X, Li C-SR. Putamen gray matter volumes in neuropsychiatric and neurodegenerative disorders. World journal of psychiatry and mental health research. 2019;3(1).
8. Schubert DS, Foliart RH. Increased depression in multiple sclerosis patients: A meta-analysis. Psychosomatics: Journal of Consultation and Liaison Psychiatry. 1993.
9. Wallin MT, Wilken JA, Turner AP, Williams RM, Kane R. Depression and multiple sclerosis: Review of a lethal combination. Journal of Rehabilitation Research & Development. 2006;43(1).
10. Mohr DC, Hart SL, Goldberg A. Effects of treatment for depression on fatigue in multiple sclerosis. Psychosomatic medicine. 2003;65(4):542-7.
11. Ziemssen T. Multiple sclerosis beyond EDSS: depression and fatigue. Journal of the neurological sciences. 2009;277:S37-S41.
12. Gay MC, Vrignaud P, Garitte C, Meunier C. Predictors of depression in multiple sclerosis patients. Acta Neurologica Scandinavica. 2010;121(3):161-70.
13. Arnett P, Randolph J. Longitudinal course of depression symptoms in multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry. 2006;77(5):606-10.
14. Patten SB, Metz LM. Depression in multiple sclerosis. Psychotherapy and Psychosomatics. 1997;66(6):286-92.
15. Janardhan V, Bakshi R. Quality of life in patients with multiple sclerosis: the impact of fatigue and depression. Journal of the neurological sciences. 2002;205(1):51-8.
16. Fruewald S, Loeffler‐Stastka H, Eher R, Saletu B, Baumhacki U. Depression and quality of life in multiple sclerosis. Acta Neurologica Scandinavica. 2001;104(5):257-61.
17. Bakshi R, Shaikh Z, Miletich R, Czarnecki D, Dmochowski J, Henschel K, et al. Fatigue in multiple sclerosis and its relationship to depression and neurologic disability. Multiple Sclerosis Journal. 2000;6(3):181-5.
18. Beiske A, Svensson E, Sandanger I, Czujko B, Pedersen E, Aarseth J, et al. Depression and anxiety amongst multiple sclerosis patients. European journal of neurology. 2008;15(3):239-45.
19. Solaro C, Gamberini G, Masuccio FG. Depression in multiple sclerosis: epidemiology, aetiology, diagnosis and treatment. CNS drugs. 2018;32(2):117-33.
20. Patten SB, Marrie RA, Carta MG. Depression in multiple sclerosis. International Review of Psychiatry. 2017;29(5):463-72.
21. Sigitova E, Fišar Z, Hroudová J, Cikánková T, Raboch J. Biological hypotheses and biomarkers of bipolar disorder. Psychiatry and clinical neurosciences. 2017;71(2):77-103.
22. Andrews G, Henderson S, Hall W. Prevalence, comorbidity, disability and service utilisation: overview of the Australian National Mental Health Survey. The British Journal of Psychiatry. 2001;178(2):145-53.
23. Schiffer RB, Wineman NM. Antidepressant pharmacotherapy of depression associated with multiple sclerosis. The American journal of psychiatry. 1990.
24. Minden SL, Orav J, Reich P. Depression in multiple sclerosis. General hospital psychiatry. 1987;9(6):426-34.
25. Joffe RT, Lippert GP, Gray TA, Sawa G, Horvath Z. Mood disorder and multiple sclerosis. Archives of Neurology. 1987;44(4):376-8.
26. Sadovnick A, Remick R, Allen J, Swartz E, Yee I, Eisen K, et al. Depression and multiple sclerosis. Neurology. 1996;46(3):628-32.
27. Chwastiak L, Ehde DM, Gibbons LE, Sullivan M, Bowen JD, Kraft GH. Depressive symptoms and severity of illness in multiple sclerosis: epidemiologic study of a large community sample. American journal of Psychiatry. 2002;159(11):1862-8.
28. Eshaghi A, Prados F, Brownlee WJ, Altmann DR, Tur C, Cardoso MJ, et al. Deep gray matter volume loss drives disability worsening in multiple sclerosis. Annals of neurology. 2018;83(2):210-22.
29. Feinstein A. An examination of suicidal intent in patients with multiple sclerosis. Neurology. 2002;59(5):674-8.
30. Shelton RC, Hollon SD, Purdon SE, Loosen PT. Biological and psychological aspects of depression. Behavior Therapy. 1991;22(2):201-28.
31. Rabins PV, Brooks BR, O'donnell P, Pearlson GD, Moberg P, Jubelt B, et al. Structural brain correlates of emotional disorder in multiple sclerosis. Brain. 1986;109(4):585-97.
32. Honer WG, Hurwitz T, Li DK, Palmer M, Paty DW. Temporal lobe involvement in multiple sclerosis patients with psychiatric disorders. Archives of Neurology. 1987;44(2):187-90.
33. Ron M, Logsdail S. Psychiatric morbidity in multiple sclerosis: a clinical and MRI study. Psychological medicine. 1989;19(4):887-95.
34. Pujol J, Bello J, Deus J, Marti-Vilalta J, Capdevila A. Lesions in the left arcuate fasciculus region and depressive symptoms in multiple sclerosis. Neurology. 1997;49(4):1105-10.
35. Zorzon M, de Masi R, Nasuelli D, Ukmar M, Pozzi Mucelli R, Cazzato G, et al. Depression and anxiety in multiple sclerosis. A clinical and MRI study in 95 subjects. Journal of neurology. 2001;248(5):416-21.
36. Cotter J, Granger K, Backx R, Hobbs M, Looi CY, Barnett JH. Social cognitive dysfunction as a clinical marker: A systematic review of meta-analyses across 30 clinical conditions. Neuroscience & Biobehavioral Reviews. 2018;84:92-9.
37. Skvarc DR, Berk M, Byrne LK, Dean OM, Dodd S, Lewis M, et al. Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies. Neuroscience & Biobehavioral Reviews. 2018;84:116-33.
38. Silveira C, Guedes R, Maia D, Curral R, Coelho R. Neuropsychiatric symptoms of multiple sclerosis: state of the art. Psychiatry investigation. 2019;16(12):877.
39. Jiang C, Zhou H, Chen L, Zhou Z. Problem Solving Therapy Improves Effortful Cognition in Major Depression. Frontiers in Psychiatry. 2021;12.
40. Arnett PA, Higginson CI, Randolph JJ. Depression in multiple sclerosis: relationship to planning ability. Journal of the International Neuropsychological Society. 2001;7(6):665-74.
41. Landrø NI, Celius EG, Sletvold H. Depressive symptoms account for deficient information processing speed but not for impaired working memory in early phase multiple sclerosis (MS). Journal of the neurological sciences. 2004;217(2):211-6.
42. Bol Y, Duits AA, Hupperts RM, Verlinden I, Verhey FR. The impact of fatigue on cognitive functioning in patients with multiple sclerosis. Clinical rehabilitation. 2010;24(9):854-62.
43. Panza F, D’Introno A, Colacicco AM, Capurso C, Del Parigi A, Caselli RJ, et al. Depressive symptoms, vascular risk factors and mild cognitive impairment. Dementia and geriatric cognitive disorders. 2008;25(4):336-46.
44. Petersen JZ, Porter RJ, Miskowiak KW. Clinical characteristics associated with the discrepancy between subjective and objective cognitive impairment in depression. Journal of Affective Disorders. 2019;246:763-74.
45. Nicholl CR, Lincoln NB, Francis VM, Stephan TF. Assessment of emotional problems in people with multiple sclerosis. Clinical rehabilitation. 2001;15(6):657-68.
46. Smith S, Young C. The role of affect on the perception of disability in multiple sclerosis. Clinical rehabilitation. 2000;14(1):50-4.
47. Krupp LB, Alvarez LA, LaRocca NG, Scheinberg LC. Fatigue in multiple sclerosis. Archives of neurology. 1988;45(4):435-7.
48. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale: application to patients with multiple sclerosis and systemic lupus erythematosus. Archives of neurology. 1989;46(10):1121-3.
49. Vercoulen JH, Hommes OR, Swanink CM, Jongen PJ, Fennis JF, Galama JM, et al. The measurement of fatigue in patients with multiple sclerosis: a multidimensional comparison with patients with chronic fatigue syndrome and healthy subjects. Archives of neurology. 1996;53(7):642-9.
50. Schwartz CE, Coulthard-Morris L, Zeng Q. Psychosocial correlates of fatigue in multiple sclerosis. Archives of physical medicine and rehabilitation. 1996;77(2):165-70.
51. Ford H, Trigwell P, Johnson M. The nature of fatigue in multiple sclerosis. Journal of psychosomatic research. 1998;45(1):33-8.
52. Schreurs KM, de Ridder DT, Bensing JM. Fatigue in multiple sclerosis: reciprocal relationships with physical disabilities and depression. Journal of psychosomatic research. 2002;53(3):775-81.
53. Hickie IB, Hooker AW, Bennett BK, Hadzi‐Pavlovic D, Wilson AJ, Lloyd AR. Fatigue in selected primary care settings: sociodemographic and psychiatric correlates. Medical Journal of Australia. 1996;164(10):585-8.
54. Feinstein A. The neuropsychiatry of multiple sclerosis. The Canadian Journal of Psychiatry. 2004;49(3):157-63.
55. Mohr DC, Boudewyn AC, Goodkin DE, Bostrom A, Epstein L. Comparative outcomes for individual cognitive-behavior therapy, supportive-expressive group psychotherapy, and sertraline for the treatment of depression in multiple sclerosis. Journal of consulting and clinical psychology. 2001;69(6):942.
56. Siegert RJ, Abernethy D. Depression in multiple sclerosis: a review. Journal of Neurology, Neurosurgery & Psychiatry. 2005;76(4):469-75.
57. Feinstein A, Magalhaes S, Richard J-F, Audet B, Moore C. The link between multiple sclerosis and depression. Nature Reviews Neurology. 2014;10(9):507-17.
58. Charil A, Filippi M. Inflammatory demyelination and neurodegeneration in early multiple sclerosis. Journal of the neurological sciences. 2007;259(1-2):7-15.
59. Husain MM, McDonald WM, Doraiswamy PM, Figiel GS, Na C, Escalona PR, et al. A magnetic resonance imaging study of putamen nuclei in major depression. Psychiatry Research: Neuroimaging. 1991;40(2):95-9.
60. Hallahan B, Newell J, Soares JC, Brambilla P, Strakowski SM, Fleck DE, et al. Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data. Biological psychiatry. 2011;69(4):326-35.
61. Hibar D, Westlye LT, van Erp TG, Rasmussen J, Leonardo CD, Faskowitz J, et al. Subcortical volumetric abnormalities in bipolar disorder. Molecular psychiatry. 2016;21(12):1710-6.
62. Rimol LM, Hartberg CB, Nesvåg R, Fennema-Notestine C, Hagler Jr DJ, Pung CJ, et al. Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder. Biological psychiatry. 2010;68(1):41-50.
63. Haber SN, Calzavara R. The cortico-basal ganglia integrative network: the role of the thalamus. Brain research bulletin. 2009;78(2-3):69-74.
64. Floresco SB. The nucleus accumbens: an interface between cognition, emotion, and action. Annual review of psychology. 2015;66:25-52.
65. Patten SB, Metz LM, Reimer MA. Biopsychosocial correlates of lifetime major depression in a multiple sclerosis population. Multiple Sclerosis Journal. 2000;6(2):115-20.
66. Diagnostic APA. Statistical Manual of mental disorders. Washington, DC: American Psychiatric Association; 1994.
67. Kenealy PM, Beaumont GJ, Lintern T, Murrell R. Autobiographical memory, depression and quality of life in multiple sclerosis. Journal of clinical and experimental neuropsychology. 2000;22(1):125-31.
68. Feinstein A, O'Connor P, Feinstein K. Multiple sclerosis, interferon beta-1b and depression. Journal of neurology. 2002;249(7):815-20.
69. Ackerman K, Rabin B, Heyman R, Frank E, Anderson B, Baum A, editors. Stressful life events precede multiple sclerosis disease exacerbations. Psychosomatic Medicine; 2000: LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA.
70. Dalos NP, Rabins PV, Brooks BR, O'Donnell P. Disease activity and emotional state in multiple sclerosis. Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society. 1983;13(5):573-7.
71. Franklin GM, Nelson LM, Heaton RK, Burks JS, Thompson DS. Stress and its relationship to acute exacerbations in multiple sclerosis. Journal of Neurologic Rehabilitation. 1988;2(1):7-11.
72. Mohr DC, Goodkin D, Bacchetti P, Boudewyn A, Huang L, Marrietta P, et al. Psychological stress and the subsequent appearance of new brain MRI lesions in MS. Neurology. 2000;55(1):55-61.
73. Group GC. The Goldman Consensus statement on depression in multiple sclerosis. Multiple Sclerosis Journal. 2005;11(3):328-37.
74.Farshidfar Z , Faeghi F,Hagighatkhah HR,Abdolmohammadi J, et al . The optimization of MRI pulse sequence in order to better detection of MS plaques in cognitive dysfucnctions.J Biomed Phys Eng.2017 sep1;7(3):265-270.PMID 29082217;PMCID:PMC5654132
75.Ashrafi F,Behnam B,Arabahmadi M,Sanei Thheri M,Haghighatkhah HR , et al.correlation of MRI findings and cognitive functions in MS patients using Montreal cognitive assessment test.Med J Islam Repub Iran.2016 Apr 17;30:357.PMD: 27453887;PMCID:PMC4934419
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |