دوره 13، شماره 3 - ( 7-1403 )
جلد 13 شماره 3 صفحات 33-24 |
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İlhan A, Kayrın L. The Impact of Leptin on Nutrition and Dietetics. J Emerg Health Care 2024; 13 (3) :24-33
URL: http://intjmi.com/article-1-1173-fa.html
URL: http://intjmi.com/article-1-1173-fa.html
The Impact of Leptin on Nutrition and Dietetics. . 1403; 13 (3) :24-33
چکیده: (561 مشاهده)
Leptin, a hormone secreted by adipose tissue, is integral to the regulation of energy balance, influencing both appetite and metabolic functions. It exerts its effects primarily on the hypothalamus, where it influences the expression of neuropeptides and communicates the body's energy status, thereby affecting food consumption and energy expenditure. Nonetheless, the regulation of energy is multifaceted, involving various factors in addition to leptin, which positions it as a crucial, albeit not exclusive, player in metabolic regulation. Current research emphasizes leptin's significant involvement in obesity, revealing that its signaling pathways are modulated by insulin and thermogenic responses, which may provide insights for nutrigenomics and tailored nutritional strategies.This review explores the physiological roles of leptin, particularly its function in appetite suppression, fat accumulation, and its interactions with other neuroendocrine signals, including insulin, ghrelin, and neuropeptide Y. Clinical investigations highlight the potential of leptin as a therapeutic agent, particularly in the management of obesity and associated metabolic disorders. Despite its promise in regulating body weight through fat mass control, the phenomenon of leptin resistance observed in obese individuals poses a significant barrier to its therapeutic application. Ongoing research into leptin-targeted therapies, especially when integrated with lifestyle modifications and personalized medicine, shows potential for effectively addressing obesity and chronic metabolic conditions.In summary, while leptin represents a valuable target for therapeutic strategies aimed at weight management and metabolic health, further investigation is essential to enhance its effectiveness and tackle the challenges posed by leptin resistance. Understanding the intricate mechanisms underlying leptin's action and its interactions with other metabolic pathways will be crucial for developing effective interventions in the fight against obesity and related metabolic disorders.
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