en عمومى General پژوهشي Research Abstract Orf or Ecthyma contagiosum is a zoonotic disease that is the result of a dermatophitic parapox virus infecting goats and sheep. The virus is transmitted to humans through contact with infected animals or fomites. Here in this paper, we reported eight patients infected with orf viruses and also tried to provide a relatively complete data of this disorder by reviewing of the literatures. Worthknowing about the disease may occur at any location, so all clinicians and researchers need to have this disease in mind as a differential diagnosis in patients who has a history of working with animals. Ecthyma contagiosum, Orf virus, Skin infection 183 186 http://intjmi.com/browse.php?a_code=A-10-1-76&slc_lang=en&sid=1 Mehrdad Taghipour 10031947532846002409 10031947532846002409 No 1Mazandaran University of Medical Sciences, Sari, Iran Farhang Babamahmoodi 10031947532846002410 10031947532846002410 Yes Antimicrobial resistance research center, Mazandaran University of Medical Sciences, Sari, Iran Parisa Arashnia 10031947532846002411 10031947532846002411 No Antimicrobial resistance research center, Mazandaran University of Medical Sciences, Sari, Iran Soveid Taghipour 10031947532846002412 10031947532846002412 No Student of Veterinary Medicine, Babol Islamic Azad University, Babol, Iran