Journal of Emergency Health Care

fa Evaluation of rs7903146 Polymorphism in TCF7L2 Gene among Type 2 Diabetes Patients عمومى General مروری Review Background: Diabetes is characterized by decreased insulin sensitivity and is a growing health threat worldwide. Therefore, this study aimed to evaluate the relationship between rs7903146 polymorphism in the TCF7L2 gene with type 2 diabetes in East Azerbaijan province, Iran. Materials and method: A total of 100 blood samples were collected from diabetic and healthy people. The samples were subjected to specific primers, PCR, and electrophoresis after DNA extraction from all samples and quality control. Finally, the PCR products were treated with RSal restriction enzyme and electrophoresed again, and the target polymorphism was checked. Results: The frequency of genotypes were TT=33.7%, CC=16.8% and CT=49.5% for healthy people and TT=43%, CC=14% and TC=43% in diabetics. The percentage of the T allele in healthy and diabetic people was as much as 42.1% and 64.5%, respectively. Conclusion: According to the results, there was probably a relationship between rs7903146 polymorphism in the TCF7L2 gene and diabetes.   Polymorphism, rs7903146, TCF7L2, Type 2 diabetes 109 114 http://intjmi.com/browse.php?a_code=A-10-1-497&slc_lang=fa&sid=1 Salar Momen Maragheh 10031947532846005411 10031947532846005411 No Biotechnology Research Center (BRC), Pasteur Institute of Iran, Tehran, Iran, Department of Biotechnology, Islamic Azad University, Central Tehran Branch, Tehran, Iran Alireza Aslani Zakariya 10031947532846005412 10031947532846005412 No Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, 25240, Turkey Elham Ghaedi 10031947532846005413 10031947532846005413 No Department of Medicine, Pirogov Russian National Research Medical University, Moscow, Russia Fahimeh Saeifar 10031947532846005414 10031947532846005414 No Department of Midwifery, Health Center of Maragheh, Maragheh, East Azerbaijan, Iran, Department of Genetics, Islamic Azad University of Bonab, Bonab, East Azerbaijan, Iran Mahdi Navid Talemi 10031947532846005415 10031947532846005415 No Department of Pharmacology, Guilan University of Medical Sciences, Rasht, Guilan, Iran Mehran Rezanezhad Varjovi 10031947532846005416 10031947532846005416 No Department of Microbiology, Islamic Azad University of Maragheh, Maragheh, East Azerbaijan, Iran Mahdi Bagheri 10031947532846005417 10031947532846005417 Yes Department of Medicine, Medical University of Ilam, Ilam, Iran