en عمومى General مروری Review Introduction: Bleeding during rhinoplasty surgery is a complication that reduces the surgeon&#39;s vision and quality of surgery and causes multiple problems for the surgeon and anesthesiologist. So far, various methods have been performed to reduce bleeding during rhinoplasty. Therefore, this study aimed to evaluate the effectiveness of medications on the rate of bleeding during rhinoplasty surgery as a systematic review of clinical trial studies conducted in Iran.<br> Methods: In this systematic review study, SID, Magiran, Scopus, Science Direct, Medline, and PubMed databases and Google Scholar search engine were quarried from 2000 to 2020 using Persian and English keywords. The quality of the included articles was evaluated using a checklist related to clinical trial studies.<br> Results: Fourteen studies were included in this study. Among the studies, 4 studies were related to tranexamic acid, 3 studies on clonidine and Dexmedetomidine, 2 studies on nitroglycerin and labetalol, and one study on remifentanil, magnesium sulfate, dexamethasone, epinephrine, and lidocaine. In all studies performed in Iran, all medications except epinephrine reduced the amount of bleeding during rhinoplasty surgery. However, some studies did not show a significant difference in reducing bleeding between the compared medications.<br> Conclusion: It seems that tranexamic acid can be more effective in reducing or controlling bleeding during rhinoplasty surgery than other medications. Bleeding, Rhinoplasty, Iran, Clinical trial. 32 40 http://intjmi.com/browse.php?a_code=A-10-1-398&slc_lang=en&sid=1 Gholamreza Motazedian 10031947532846004457 10031947532846004457 No Assistant Professor of Plastic & Reconstructive Surgery, Shiraz University of Medical Sciences, Shiraz, Iran. Mojtaba Sohrabpour 10031947532846004458 10031947532846004458 No Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. Mohammad Sadegh Sanie Jahromi 10031947532846004459 10031947532846004459 No Anesthesiology, Critical Care And Pain Management Research Center, Jahrom University Of Medical Sciences, Jahrom, Iran. Mojtaba Ghaedi 10031947532846004460 10031947532846004460 Yes Assistant Professor of Plastic Surgery, Jahrom University Of Medical Sciences, Jahrom, Iran.