fa عمومى General پژوهشي Research <div style="text-align: justify;">In this paper, we conducted a Bayesian Network Meta-analysis of the latest COVID-19 clinical trials including 5 studies on 591 patients receiving 4 different agents of Arbidol, Favipiravir, lopinavir- ritonavir, and Hydroxychloroquine and standard treatment protocol. We ranked the best agent based&nbsp;on patient improvement using Markov-Monte-Carlo-Chain. Hydroxychloroquine showed the best&nbsp;efficiency following the Favipiravir, Arbidol, lopinavir-ritonavir, and standard regimen in the first&nbsp;week of treatment. In the second week, with excluding Hydroxychloroquine arm (as some reporting&nbsp;studies hadn&#39;t addressed its efficacy in the second week), Favipiravir was the best treatment following&nbsp;by lopinavir-ritonavir, standard care, and Arbidol. As we saw a huge change in the ranking of the&nbsp;drugs by evaluating outcomes in the second week of treatment, we think that COVID-19 randomized&nbsp;clinical trials should be performed based on a standard study protocol worldwide, that could help&nbsp; policy makers to make a decision on the treatment protocol.</div> Network Meta-analysis, Favipiravir, SARS-CoV-2, COVID-19, lopinavir-ritonavir. 1 4 http://intjmi.com/browse.php?a_code=A-10-1-310&slc_lang=fa&sid=1 Farshid Javdani 10031947532846003831 10031947532846003831 Yes Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran. Mohammad Hashem Abdi 10031947532846003832 10031947532846003832 No Department of Nursing, Jahrom University of Medical Sciences, Jahrom, Iran. Samaneh Abiri 10031947532846003833 10031947532846003833 No Research center for social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran. Marzieh Haghbeen 10031947532846003834 10031947532846003834 No Research center for social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran. Ahmad Rastgarian 10031947532846003835 10031947532846003835 No Anesthesiology, Critical care and pain management research center, Jahrom University of Medical Sciences, Jahrom, Iran. Mohammad Hasan Damshenas 10031947532846003836 10031947532846003836 No Anesthesiology, Critical care and pain management research center, Jahrom University of Medical Sciences, Jahrom, Iran. Pouyan Keshavarz 10031947532846003837 10031947532846003837 No Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran. Mohammad Amin Akbarnejad 10031947532846003838 10031947532846003838 No Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran. Naser Hatami 10031947532846003839 10031947532846003839 No Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran. Sayyed Reza Ahmadi 10031947532846003840 10031947532846003840 No Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Seyed Reza Habibzadeh 10031947532846003841 10031947532846003841 No Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Neema John Mehramiz 10031947532846003842 10031947532846003842 No Department of Psychiatry Neurology. Banner university medical center, Tucson, AZ, USA. Mahdi Foroughian 10031947532846003843 10031947532846003843 No Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Navid Kalani 10031947532846003844 10031947532846003844 No Research center for social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran.