en عمومى General گزارش مورد case report Primary hyperparathyroidism (PHPT) is a disease caused by excessive secretion of parathyroid hormone (PTH), and occurs because of individual parathyroid adenomas.in this report we discussed prgnant 25 female who suffered from as weakness, lethargy, nausea and vomiting . Primary experimental results suggested severe hypercalcemia. Ultrasonography of patient’s neck revealed a cystic thyroid nodule (12.8mm) in mid of right lube. The observation suggested normal parotid and submandibular glands.Based on ultrasound and MRI results, the patient received protective treatment. Early diagnosis can helpful to best managament of primary hyperparathyroidism especially during the pregnancy. Primary hyperparathyroidism, pregnancy, hypercalcemia 93 98 http://intjmi.com/browse.php?a_code=A-10-1-178&slc_lang=en&sid=1 Tahereh Babaei 10031947532846002812 10031947532846002812 No Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran Arash Rezaei Shahmirzadi 10031947532846002813 10031947532846002813 No Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran Hossein Ghanadanhili 10031947532846002814 10031947532846002814 No Department of neurology, Clinical Research Development Unit (CRDU), Sayad Shirazi hospital, Golestan University of Medical Sciences, Gorgan, Iran Seyed Arad Mosalammi Aghili 10031947532846002815 10031947532846002815 No School of medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Seyed Fateme Zahra Hashemi Tervejeni 10031947532846002816 10031947532846002816 No Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran. Hamide Akbari 10031947532846002817 10031947532846002817 Yes Department of endocrinology, Clinical Research Development Unit (CRDU), Sayad Shirazi hospital, Golestan University of Medical Sciences, Gorgan, Iran.