en عمومى General گزارش مورد case report Osteogenesis Imperfecta (OI) or Brittle bone disease, is a rare genetic disorder that causes type I collagen synthesis disturbance results in bone fragility. We present a female newborn which had numerous fractures in the arm and femur. Her delivery was at 38 weeks gestation by caesarean section. Prenatal ultrasound revealed bone swelling and long bones shortness. The patient is pale blue sclera. 36 days after birth, the patient had a fracture in her left femur. Genetic analysis of the patient was reported. Protests by clinical, ultrasound and x-ray taken during pregnancy for this patient reported Osteogenesis Imperfecta type V. shortening, swelling and deformity of the long bones during prenatal sonography can prove Osteogenesis Imperfecta before birth and select the correct orthopedic plan for treatment. Osteogenesis Imperfecta, multiple fractures, collagen type I 0 0 http://intjmi.com/browse.php?a_code=A-10-1-103&slc_lang=en&sid=1 Mohammad Hossein Kariminasab 1003194753284600841 1003194753284600841 Yes Masoud Shayeste-Azar 1003194753284600842 1003194753284600842 No Majid SajjadiSaravi 1003194753284600843 1003194753284600843 No Seyed Mohamad Mehdi Daneshpoor 1003194753284600844 1003194753284600844 No Milad Bahari 1003194753284600845 1003194753284600845 No Mehran Fazli 1003194753284600846 1003194753284600846 No Mahdi shayesteh azar 1003194753284600847 1003194753284600847 No