en عمومى General مروری Review <span style="font-size:11pt"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif"><b>Background:</b>&nbsp;Asthma is a complex and heterogeneous disease characterized by chronic inflammation, airway remodeling, and variable clinical manifestations. Despite advances in asthma management, there is a need for novel biomarkers to improve diagnosis, predict disease severity, and monitor treatment responses.</span></span></span><br> <span style="font-size:11pt"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif"><b>Objective:</b>&nbsp;To review the current evidence on the role of YKL-40 and dipeptidyl peptidase-4 (DPP-4) in asthma, including their potential as biomarkers for disease severity, treatment responses, and genetic predisposition.</span></span></span><br> <span style="font-size:11pt"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif"><b>Methods:</b>&nbsp;A comprehensive literature search was conducted to identify studies investigating the relationship between YKL-40, DPP-4, and asthma. Relevant articles were selected based on their relevance to the topic and study design.</span></span></span><br> <span style="font-size:11pt"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif"><b>Results:</b>&nbsp;The review highlights the association of YKL-40 with airway remodeling, inflammation, and disease severity in asthma. Elevated YKL-40 levels have been linked to poor prognosis, increased exacerbations, and reduced lung function. Genetic variations in the CHI3L1 gene, which encodes YKL-40, have been associated with asthma susceptibility and severity. DPP-4 has been implicated in the regulation of inflammation and immune responses in asthma, with studies suggesting its potential role in modulating airway inflammation and remodeling.</span></span></span><br> <span style="font-size:11pt"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif"><b>Conclusion:</b>&nbsp;YKL-40 and DPP-4 are promising biomarkers for asthma, with potential applications in disease diagnosis, severity assessment, and treatment monitoring. Further research is needed to fully elucidate their roles in asthma pathophysiology and to explore their clinical utility in asthma management.</span></span></span><br> &nbsp; Asthma, YKL-40, Dipeptidyl Peptidase-4, Biomarkers, Airway Remodeling, Inflammation, Genetic Predisposition, Disease Severity, Treatment Responses. 192 201 http://intjmi.com/browse.php?a_code=A-10-1-630&slc_lang=en&sid=1 Alireza Pournouri 10031947532846007077 0009-0001-2570-6523 No Departmant of community medicine, Dezful, Iran Mahsa Asadi 10031947532846007078 0009-0009-2412-1409 Yes Research committee of Dezful University of Medical Sciences, Dezful, Iran